Osong Public Health Res Perspect.
2021 Oct;12(5):278-285. 10.24171/j.phrp.2021.0153.
The role of lipids in the pathophysiology of coronavirus infections
- Affiliations
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- 1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- 2Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
- 3Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran
- 4Department of Medical Biotechnology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
- 5Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- KMID: 2523340
- DOI: http://doi.org/10.24171/j.phrp.2021.0153
Abstract
- Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.
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