Korean J Ophthalmol.  2021 Dec;35(6):448-454. 10.3341/kjo.2021.0037.

Correlation between Topographic Progression of Geographic Atrophy and Visual Acuity Changes

• You JI
• Kim DG
• Yu SY
• Kim ES
• Kim K

• KMID: 2523037
• DOI: http://doi.org/10.3341/kjo.2021.0037

Abstract

Purpose
To analyze topographic progression of geographic atrophy with different concentric circles centered on the fovea in correlation with decrease of visual acuity.
Methods
We retrospectively analyzed 36 eyes of 26 patients diagnosed with geographic atrophy and followed at least 1 year. One millimeter circular area at the foveal center were defined as zone 1, and doughnut shape areas from between 1 and 2 mm to between 5 and 6 mm were defined as zone 2 to 6. Then, changes of geographic atrophy area in each zone were measured with semi-automatic software. Correlation analysis and regression analysis were performed to determine the relationship between changes in visual acuity and atrophic area in each zone.
Results
Mean age was 76.9 years and follow-up period were 3.38 years. The mean atrophic area increased from 8.09 to 16.34 mm² and visual acuity decreased from 0.39 to 0.69 on logarithm of the minimal angle of resolution. Mean change of total geographic atrophy area was not significantly correlated with visual acuity decrease. While geographic atrophy progression within zone 1, 2, and 3 showed significant causal relationship with decrease of visual acuity (all, p < 0.05).
Conclusions
In contrast to the total geographic atrophy area, progression of geographic atrophy in parafoveal area was significantly correlated with decrease of visual acuity.

Keyword

Fundus autofluorescence; Geographic atrophy; Macular degeneration