J Korean Ophthalmol Soc.  1995 Sep;36(9):1568-1573.

Evaluation of VEP in Optic Nerve Diseases and Amblyopia

• Park HK
• Kim MM
• Hahn DK

Abstract

We performed full field pattern reversal VEP using UTAS-E 2000, in 87 eyes of the 70 patients with amblyopia(14 eyes) and optic nerve diseases; optic neuritis(21 eyes), optic nerve atrophy(23 eyes), toxic optic neuropathy(15 eyes) and optic nerve injury(14 eyes) from December 1993 to July 1994. This study was carried out to evaluate the relationship of the visual acuity with P1 amplitude, P1 latency, and to compare the latency of P1, and P1-N2 amplitude to each disease group and the normal groups. There was no correlation between the visual acuity and P1 latency, but significant correlation between the visual acuity and P1 amplitude(p<0.01). In the P1 implicit time, optic neuritis, optic nerve atrophy and toxic optic neuropathy patients presented marked delay and amblyopia patients presented moderate delay, but there was no other significant difference in each disease group. Over 50% of each disease group except amblyopia presented P1 destruction. Therefore, the authers concluded that P1 amplitude might not be good parameter in diagnosis of the optic nerve disease because of its variability to the visual acuity, but P1 latency and P1 destruction could be good parameter.

Keyword

Amblyopia; Optic neuritis; Optic nerve atrophy; Optic nerve injury; Toxic optic neuropathy

MeSH Terms

Amblyopia*
Atrophy
Diagnosis
Humans
Optic Nerve Diseases*
Optic Nerve Injuries
Optic Nerve*
Optic Neuritis
Visual Acuity