Clin Exp Pediatr.  2021 Dec;64(12):642-651. 10.3345/cep.2020.01676.

Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review

• Shirazinia R
• Golabchifar AA
• Fazeli MR

• KMID: 2522665
• DOI: http://doi.org/10.3345/cep.2020.01676

Abstract

Background
Infantile colic (IC) is excessive crying in otherwise healthy children. Despite vast research efforts, its etiology remains unknown. Purpose: Most treatments for IC carry various side effects. The collection of evidence may inform researchers of new strategies for the management and treatment of IC as well as new clues for understanding its pathogenesis. This review and meta-analysis aimed to evaluate the efficacy and possible mechanisms of probiotics for mananaging IC.
Methods
Ten papers met the study inclusion and exclusion criteria, and the meta-analysis was conducted using Review Manager (RevMan) software and a random-effects model.
Results
This meta-analysis revealed that probiotics are effective for treating infantile colic, while the review showed that this efficacy may be due to their anti-inflammatory effects.
Conclusion
Probiotics may be an important treatment option for managing infantile colic due to their anti-inflammatory properties.

Keyword

Infantile colic; Cytokines; Meta-analysis; Gastrointestinal inflammation; Probiotics