Immune Netw.
2021 Apr;21(2):e14. 10.4110/in.2021.21.e14.
Intranasal Vaccination with OuterMembrane Protein of Orientia tsutsugamushi induces Protective Immunity Against Scrub Typhus
- Park SM
1 - Gu MJ1
- Ju YJ1
- Cheon IS1,2
- Hwang KJ3
- Gill B3
- Shim BS2
- Jeong HJ3
- Son YM1
- Choi S3
- Jeung W1
- Han SH4
- Chu H3
- Yun CH1,5,6
- Affiliations
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- 1Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
- 2Laboratory Sciences Division, International Vaccine Institute, Seoul 08826, Korea
- 3Division of Zoonotic and Vector Borne Disease Research, Center for Infectious Disease Research, National Institute of Health, Cheongju 28159, Korea
- 4Department of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul 08826, Korea
- 5Institutes of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea
- 6Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul 08826, Korea
- KMID: 2522160
- DOI: http://doi.org/10.4110/in.2021.21.e14
Abstract
- Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.
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