Environ Anal Health Toxicol.  2021 Sep;36(3):e2021019. 10.5620/eaht.2021019.

Acute toxicity assessment for TiO₂ photocatalyst (GST) made from wastewater using TiCl₄ in rat

• Seol JK
• Park M
• Im JM
• Seo HS
• Park HJ
• Nah SS

• KMID: 2521970
• DOI: http://doi.org/10.5620/eaht.2021019

Abstract

TiO₂ was a photocatalyst that used to the most common product because of the high efficiency. TiO₂ (P-25, commercial nanomaterial product) is the most typical photocatalyst product and TiO₂ (GST) was a sludge recycling product. This study was reported to evaluate an acute toxicity of TiO₂ (P-25 and GST) according to OECD test guideline 402 and 423 in Sprague-Dawley (SD) female rats via route of oral and dermal. There was investigated the lethal dose (LD₅₀), and mortality, clinical signs, body weight changes and gross findings were continually monitored for 14 days following the single administration. After administration, TiO₂ (P-25) was calculated that LD₅₀ was considered to be a dose of over 2000 mg/kg body weight for both different route of exposure, and TiO₂ (GST) was the same. Other items were no observed an adverse effect between P-25 and GST; no mortality and clinical signs, accidental body weight loss, no gross findings. On the basis of the above results, the toxicity of the GST was almost equal to that of the commercial product, P-25 and there was no toxicological evidence.

Keyword

GST; P-25; oral; dermal; TiO₂; nanomaterial