J Korean Ophthalmol Soc.  2021 Oct;62(10):1333-1339. 10.3341/jkos.2021.62.10.1333.

Clinical Outcomes of Orbital Exenteration in Korean Patients with Orbital Malignancies

• Son WY
• Park NR
• Kim SE
• Yang SW

• KMID: 2521634
• DOI: http://doi.org/10.3341/jkos.2021.62.10.1333

Abstract

Purpose
We report the clinical outcomes of Korean patients who were diagnosed with orbital malignancies and underwent orbital exenteration.
Methods
We retrospectively reviewed the tumor origins, histopathological diagnoses, local/regional recurrences, distant metastases, surgical margin clearances, overall and event-free survivals, and adjuvant chemotherapy or radiation therapy statuses of 14 patients who underwent orbital exenteration in our center from February 2009 to March 2020.
Results
We enrolled seven men and seven women of mean age at the time of exenteration of 68 years (range, 37 to 80 years). The mean follow-up period was 44.6 months (range, 10 to 133 months). Most tumors had arisen in the eyelid (seven cases, 50.0%). The most common pathological diagnosis was malignant melanoma (five cases, 35.7%). We observed no local or regional recurrence after exenteration, but distant metastases developed in seven cases, of which four were malignant melanomas (80% of all melanomas). Positive surgical margins were observed in six cases (42.9%). The distant metastasis rate was 42.9%; the overall survival rate was 60%. The 1-year overall survival rate was 100%, the 2-year survival rate was 81.8%, and the 5-year survival rate was 56.1%. The 1-year event-free survival (EFS) rate was 100%, the 2-year EFS rate was 72.7%, and the 5-year EFS rate was 49.9%. Nine patients received adjuvant radiation or chemotherapy and six patients received combined chemoradiation.
Conclusions
Patients underwent orbital exenteration to treat orbital malignancies and received postoperative chemotherapy and/or radiation exhibited differences in clinical outcomes and survival rates depending on the tumor type.

Keyword

Exenteration, Orbit, Orbital exenteration, Orbital malignancy