Korean J Transplant.  2021 Oct;35(Supple 1):S62. 10.4285/ATW2021.PO-1116.

Effects of platelet rich plasma on ureteroneocystostomy in rabbits

• Smagulov A
• Mussin N

• KMID: 2521414
• DOI: http://doi.org/10.4285/ATW2021.PO-1116

Abstract

Background
The aim of this study is to study the role of platelet-rich plasma (PRP) on the healing of ureteroneocystostomy (UCA) in a rabbit model.
Methods
A total of 14 adult male New Zealand rabbits (Oryctolagus cuniculus) were divided into two groups: group I (n=7), standard anastomosis without PRP; group II (n=7), standard anastomosis with PRP. The animals were observed for 7 days, then killed. The parameters of the study were complications of anastomosis, evaluation of hydroxyproline and histopathological evaluation of anastomoses.
Results
The level of hydroxyproline was statistically higher in the PRP group than in the control group (P<0.05). Histological evaluation of the anastomoses showed almost complete healing in all animals. The average histological parameters of the animals in the groups did not differ.
Conclusions
According to our results, we assume that the use of PRP improves the healing of the anastomosis due to the level of hydroxyproline and a decrease in the inflammatory response. Further clinical studies are needed to confirm our hypothesis.