J Obes Metab Syndr.
2021 Sep;30(3):261-270. 10.7570/jomes20137.
Framingham Risk Score Assessment in Subjects with Pre-diabetes and Diabetes: A Cross-Sectional Study in Korea
- Affiliations
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- 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 2Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea.
- 5Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
- 6Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
- 7Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- 8Department of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
- 9Medical Department, Sanofi-Aventis Korea, Seoul, Korea.
- 10Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
- 11Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea.
- KMID: 2521074
- DOI: http://doi.org/10.7570/jomes20137
Abstract
- Background
This study aimed to evaluate cardiovascular risk in subjects with pre-diabetes and diabetes in Korea.
Methods
In this pan-Korean, non-interventional, cross-sectional study, data were collected from medical records of 10 hospitals between November 2013 and June 2014. Subjects (aged ≥40 years) with medical records of dysglycemia and documentation of total cholesterol level, high-density lipoprotein cholesterol level, systolic blood pressure, and smoking status in the past 6 months were included. The primary endpoint was to determine the Framingham risk score (FRS). The relationships between FRS and cardiovascular risk factors, glycated hemoglobin, and insulin usage were determined by multiple linear regression analyses.
Results
Data from 1,537 subjects with pre-diabetes (n= 1,025) and diabetes (n= 512) were analyzed. The mean FRS (mean±standard deviation) in subjects with pre-diabetes/diabetes was 13.72±8.77. FRS was higher in subjects with diabetes than pre-diabetes (P<0.001). FRS in men with pre-diabetes was comparable to that in women with diabetes (13.80±7.37 vs. 13.35±7.13). FRS was elevated in subjects who consumed alcohol (2.66, P= 0.033) and with obesity-class II (6.10, P= 0.015) among subjects with diabetes (n= 199), and was elevated in patients with left ventricular hypertrophy (11.10, P= 0.005), those who consumed alcohol (3.06, P= 0.000), were pre-obese (3.21, P= 0.002), or were obesity-class I (2.89, P= 0.002) among subjects with pre-diabetes (n= 306) in comparison to subjects without these coexisting risk factors.
Conclusion
Overall, Korean subjects with pre-diabetes and diabetes have an increased cardiovascular risk, which is significantly higher in those subjects with diabetes than with pre-diabetes. The present data can be used to develop measures to prevent and manage cardiovascular complications in Koreans with impaired glucose metabolism
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