Lab Anim Res.
2021 Sep;37(3):156-184. 10.1186/s42826-021-00103-2.
Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
- Affiliations
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- 1Division of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea
- 2Division of Applied Life Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 52828, Republic of Korea
- 3Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Republic of Korea
- 4Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
- 5Department of Biological Sciences, Sookmyung Women’s University, Seoul 04310, Republic of Korea
- 6Department of Marine Life Sciences and Fish Vaccine Research Center, Jeju National University, Jeju 63243, Republic of Korea
- 7Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea
- 8Department of Biomedical Sciences, College of Medicine, Korea University, Ansan 15355, Republic of Korea
- 9Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon 34134, Republic of Korea
- KMID: 2521032
- DOI: http://doi.org/10.1186/s42826-021-00103-2
Abstract
- Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.
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