Ann Clin Microbiol.  2021 Sep;24(3):97-104. 10.5145/ACM.2021.24.3.4.

Fecal Microbiota Transplantation against Gut Colonization Using a Multidrug-Resistant Organism

Affiliations
  • 1Division of Healthcare Technology Assessment Research, Seoul, Korea
  • 2Division for New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea
  • 3Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea

Abstract

Background
Fecal microbiota transplantation against gut colonization using a multidrugresistant organism is a technique used to treat infections through normalizing the gut microbiota via fecal microbiota transplantation in patients with confirmed colonization by carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) based on a fecal culture test within the past one week. In this study, we aimed to determine the safety and effectiveness of this technique.
Methods
The safety and effectiveness were assessed via a systematic review. A literature search was conducted using five Korean databases, such as KoreaMed, and international databases, including Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library.
Results
Main results are described here. From the studies retrieved using the aforementioned search strategy, the remaining 581 studies were screened using the inclusion and exclusion criteria, resulting in the selection of nine studies for further consideration. In terms of safety, many studies reported deaths and adverse reactions associated with different causes. Fewer studies reported the rate of colonization; however, the effect of colony rate was inconsistent when compared to no treatment group. Additionally, none of the studies assessed the recurrence rate, a decrease in the prevalence of diseases related to infection by multidrugresistant bacteria, and the quality of life.
Conclusion
Fecal bacterial colonization for the decolonization of intestinal multidrugresistant bacteria was evaluated using a technique that requires further research as there is insufficient literature evidence to validate its safety and efficacy in treating infections through normalizing the intestinal flora of patients with confirmed colonization by CRE or VRE.

Keyword

Fecal microbiota transplantation; Gut colonization; Multidrug-resistant organism
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