J Korean Neurol Assoc.
2021 Aug;39(3):214-218. 10.17340/jkna.2021.3.19.
Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
- Affiliations
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- 1Department of Neurology, Ajou University School of Medicine, Suwon, Korea
- 2Department of Anatomy, Ajou University School of Medicine, Suwon, Korea
- KMID: 2518945
- DOI: http://doi.org/10.17340/jkna.2021.3.19
Abstract
- We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
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