Korean J Radiol.
2021 Aug;22(8):1310-1322. 10.3348/kjr.2020.1299.
Immunotherapy-Related Imaging Findings in Patients with Gynecological Malignancies: What Radiologists Need to Know
- Russo L
1 - Avesani G1
- Gui B1
- Trombadori CML2
- Salutari V3
- Perri MT4
- Paola VD1
- Rodolfino E1
- Scambia G3,4
- Manfredi R1,2
- Affiliations
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- 1UOC Radiologia Generale ed Interventistica Generale, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Area Diagnostica per Immagini, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- 2Dipartimento Universitario di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
- 3UOC Ginecologia Oncologica, Dipartimento per la Salute della Donna e del Bambino e della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- 4Istituto di Ginecologia e Ostetricia, Università Cattolica del Sacro Cuore, Rome, Italy
- KMID: 2518715
- DOI: http://doi.org/10.3348/kjr.2020.1299
Abstract
- Immunotherapy is an effective treatment option for gynecological malignancies. Radiologists dealing with gynecological patients undergoing treatment with immune checkpoint inhibitors should be aware of unconventional immune-related imaging features for the evaluation of tumor response and immune-related adverse events. In this paper, immune checkpoint inhibitors used for gynecological malignancies and their mechanisms of action are briefly presented. In the second part, patterns of pseudoprogression are illustrated, and different forms of immune-related adverse events are discussed.
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