Nat Prod Sci.
2021 Jun;27(2):68-77. 10.20307/nps.2021.27.2.68.
The Pharmacological Properties of Silymarin and Its Constituents
- Affiliations
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- 1Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Banten 15314, Indonesia
- 2Research Center for Chemistry, National Research and Innovation Agency (BRIN), Banten 15314, Indonesia
- 3Center for Research and Development for Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta 10560, Indonesia
- KMID: 2517549
- DOI: http://doi.org/10.20307/nps.2021.27.2.68
Abstract
- Silymarin is a standardized extract obtained from the seeds and fruits of Silybum marianum L., or commonly called milk thistle, a member of Carduus marianum family that contains mix of flavonolignans. Some epidemiological and preclinical studies revealed that S. marianum L. has been used for herbal remedies for centuries for its pharmacological activity. In this review, pharmacological studies in vitro and in vivo of silymarin are discussed thoroughly stressing on antioxidant, antimicrobial, antiviral, and anti-carcinogenic aspects of silymarin. In addition, the protective influences of silymarin on some organs such as heart, liver, bone, and neuron tissue are reviewed as well. This review would be useful for further study regarding the potential of natural plant, notably silymarin, and its therapeutic potential in the prevention and treatment of diseases.
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