Korean J Pain.  2021 Jun;34(3):288-303. 10.3344/kjp.2021.34.3.288.

Multicenter survey of symptoms, work life, economic status, and quality of life of complex regional pain syndrome patients

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea
  • 2Department of Anesthesiology and Pain Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
  • 3Department of Anesthesiology and Pain Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea
  • 4Department of Anesthesiology and Pain Medicine, Jeong-clinic, Seoul, Korea
  • 5Department of Anesthesiology and Pain Medicine, Inje University Seoul Paik Hospital, Seoul, Korea
  • 6Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Jeju, Korea
  • 7Department of Anesthesiology and Pain Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea

Abstract

Background
Complex regional pain syndrome (CRPS) is an intractable pain disease with various symptoms. Here, we investigated the disease status, work life, sleep problems, medical insurance, economic status, psychological problems, and quality of life (QOL) of CRPS patients.
Methods
CRPS patients from 37 university hospitals in South Korea were surveyed. The survey questionnaire consisted of 24 questions on the following aspects of CRPS patients: sex, age, occupation, cause of injury, activities of daily living (ADL), pain severity, sleep disturbance, level of education, economic status, therapeutic effect, and suicidal ideation. Additionally, the abbreviated World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, consisting of 26 questions, was used to identify the status of QOL.
Results
A total of 251 patients completed the questionnaire. According to the survey, 54.2% patients could not perform ADL on their own. Over the previous week, the mean pain score was 7.15 ± 1.78 (out of a total of 10 points); 92.1% of patients had sleep disorders and 80.5% had suicidal ideation, with most patients suffering from psychological problems. The average for each domain of WHOQOL-BREF was as follows: 21.74 ± 14.77 for physical, 25.22 ± 17.66 for psychological, 32.02 ± 22.36 for social relationship, and 30.69 ± 15.83 for environmental (out of a total of 100 points each). Occupation, ADL, sleep time, therapeutic effect, and suicidal ideation were statistically correlated with multiple domains.
Conclusions
Most patients had moderate to severe pain, economic problems, limitations of their ADL, sleep problems, psychological problems, and a low QOL score.

Keyword

Activities of Daily Living; Chronic Pain; Complex Regional Pain Syndromes; Economic Status; Educational Status; Occupations; Pain; Intractable; Quality of Life; Sleep Wake Disorders; Suicidal Ideation; Surveys and Questionnaires

Figure

  • Fig. 1 Representation of data for occupational changes in patients before and after complex regional pain syndrome (CRPS) outbreak.

  • Fig. 2 Representation of data for time span for diagnosis of complex regional pain syndrome.

  • Fig. 3 Representation of data for the degree of activity of daily living (ADL) of complex regional pain syndrome patients.

  • Fig. 4 Representation of data for prevalence of sleep disturbance caused by pain in complex regional pain syndrome patients.

  • Fig. 5 Representation of data for impact of complex regional pain syndrome on economic activities and economic difficulties among patients.

  • Fig. 6 Representation of data for prevalence of suicidal ideation in complex regional pain syndrome patients.


Cited by  3 articles

Impact of coronavirus disease 2019 on patients with chronic pain: multicenter study in Korea
Hyunji John, Yun Hee Lim, Sung Jun Hong, Jae Hun Jeong, Hey Ran Choi, Sun Kyung Park, Jung Eun Kim, Byung-soo Kim, Jae Hun Kim
Korean J Pain. 2022;35(2):209-223.    doi: 10.3344/kjp.2022.35.2.209.

Re: Multicenter survey of symptoms, work life, economic status, and quality of life of complex regional pain syndrome patients
Sunghwan Cho
Korean J Pain. 2022;35(2):231-232.    doi: 10.3344/kjp.2022.35.2.231.

Actual situation and prescribing patterns of opioids by pain physicians in South Korea
Min Jung Kim, Ji Yeon Kim, Yun Hee Lim, Sung Jun Hong, Jae Hun Jeong, Hey Ran Choi, Sun Kyung Park, Jung Eun Kim, Min Ki Lee, Jae Hun Kim
Korean J Pain. 2022;35(4):475-487.    doi: 10.3344/kjp.2022.35.4.475.


Reference

1. Maihöfner C, Seifert F, Markovic K. 2010; Complex regional pain syndromes: new pathophysiological concepts and therapies. Eur J Neurol. 17:649–60. DOI: 10.1111/j.1468-1331.2010.02947.x. PMID: 20180838.
Article
2. Chae WS, Kim SH, Cho SH, Lee JH, Lee MS. 2016; Reduction in mechanical allodynia in complex regional pain syndrome patients with ultrasound-guided pulsed radiofrequency treatment of the superficial peroneal nerve. Korean J Pain. 29:266–9. DOI: 10.3344/kjp.2016.29.4.266. PMID: 27738506. PMCID: PMC5061644.
Article
3. Jeon SG, Choi EJ, Lee PB, Lee YJ, Kim MS, Seo JH, et al. 2014; Do severity score and skin temperature asymmetry correlate with the subjective pain score in the patients with complex regional pain syndrome? Korean J Pain. 27:339–44. DOI: 10.3344/kjp.2014.27.4.339. PMID: 25317283. PMCID: PMC4196499.
Article
4. Shin NY, Kang DH, Jang JH, Park SY, Hwang JY, Kim SN, et al. 2013; Impaired recognition of social emotion in patients with complex regional pain syndrome. J Pain. 14:1304–9. DOI: 10.1016/j.jpain.2013.05.008. PMID: 23876283.
Article
5. Marinus J, Van Hilten JJ. 2006; Clinical expression profiles of complex regional pain syndrome, fibromyalgia and a-specific repetitive strain injury: more common denominators than pain? Disabil Rehabil. 28:351–62. DOI: 10.1080/09638280500287320. PMID: 16492631.
Article
6. Kim H, Lee CH, Kim SH, Kim YD. 2018; Epidemiology of complex regional pain syndrome in Korea: an electronic population health data study. PLoS One. 13:e0198147. DOI: 10.1371/journal.pone.0198147. PMID: 29864152. PMCID: PMC5986148.
Article
7. Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. 2015; A classification of chronic pain for ICD-11. Pain. 156:1003–7. DOI: 10.1097/j.pain.0000000000000160. PMID: 25844555. PMCID: PMC4450869.
Article
8. Fishman S, Ballantyne J, Rathmell JP, Bonica JJ. 2010. Bonica's management of pain. 4th ed. Williams & Wilkins;Baltimore, Lippincott: p. xxxiii. p. 1661.
9. Harden RN, Oaklander AL, Burton AW, Perez RS, Richardson K, Swan M, et al. 2013; Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med. 14:180–229. DOI: 10.1111/pme.12033. PMID: 23331950.
Article
10. Rand SE, Basu S, Khalid S. 2019; Complex regional pain syndrome: current diagnostic and treatment considerations. Curr Sports Med Rep. 18:325–9. DOI: 10.1249/JSR.0000000000000633. PMID: 31503044.
11. Sohn HS, Lee DH, Lee KJ, Noh EC, Choi SH, Jang JH, et al. 2016; Impaired empathic abilities among patients with Complex Regional Pain Syndrome (Type I). Psychiatry Investig. 13:34–42. DOI: 10.4306/pi.2016.13.1.34. PMID: 26766944. PMCID: PMC4701683.
Article
12. Goebel A. 2011; Complex regional pain syndrome in adults. Rheumatology (Oxford). 50:1739–50. DOI: 10.1093/rheumatology/ker202. PMID: 21712368.
Article
13. Bruehl S, Harden RN, Galer BS, Saltz S, Bertram M, Backonja M, et al. 1999; External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria. International Association for the Study of Pain. Pain. 81:147–54. DOI: 10.1016/S0304-3959(99)00011-1. PMID: 10353502.
14. Lee WJ, Jung CH, Hwang JY, Seong SJ, Han CH, Park JW, et al. 2019; Prognostic factors in complex regional pain syndrome type 1 occurring in the Korean army. Pain Med. 20:1989–96. DOI: 10.1093/pm/pnz076. PMID: 30986307.
Article
15. Galer BS, Henderson J, Perander J, Jensen MP. 2000; Course of symptoms and quality of life measurement in Complex Regional Pain Syndrome: a pilot survey. J Pain Symptom Manage. 20:286–92. DOI: 10.1016/S0885-3924(00)00183-4. PMID: 11027911.
16. Birklein F, O'Neill D, Schlereth T. 2015; Complex regional pain syndrome: an optimistic perspective. Neurology. 84:89–96. DOI: 10.1212/WNL.0000000000001095. PMID: 25471395.
Article
17. Grieve S, Llewellyn A, Jones L, Manns S, Glanville V, McCabe CS. 2019; Complex regional pain syndrome: an international survey of clinical practice. Eur J Pain. 23:1890–903. DOI: 10.1002/ejp.1463. PMID: 31376299.
Article
18. Littlejohn G. 2013; Therapy: bisphosphonates for early complex regional pain syndrome. Nat Rev Rheumatol. 9:199–200. DOI: 10.1038/nrrheum.2013.6. PMID: 23358509.
Article
19. Kang JE, Kim YC, Lee SC, Kim JH. 2012; Relationship between complex regional pain syndrome and working life: a Korean study. J Korean Med Sci. 27:929–33. DOI: 10.3346/jkms.2012.27.8.929. PMID: 22876061. PMCID: PMC3410242.
Article
20. Li Z, Smith BP, Smith TL, Koman LA. 2005; Diagnosis and management of complex regional pain syndrome complicating upper extremity recovery. J Hand Ther. 18:270–6. DOI: 10.1197/j.jht.2005.02.005. PMCID: PMC1370263. PMID: 15891984.
Article
21. Ok SJ, Yang JY, Son JH, Jeong WJ, Lee YS, Kim WY, et al. 2010; Management of complex regional pain syndrome type 1 with total spinal block. Korean J Pain. 23:70–3. DOI: 10.3344/kjp.2010.23.1.70. PMID: 20552078. PMCID: PMC2884217.
Article
22. Chen CK, Phui VE, Nizar AJ, Yeo SN. 2013; Percutaneous t2 and t3 radiofrequency sympathectomy for complex regional pain syndrome secondary to brachial plexus injury: a case series. Korean J Pain. 26:401–5. DOI: 10.3344/kjp.2013.26.4.401. PMID: 24156009. PMCID: PMC3800715.
Article
23. Woolf CJ, Salter MW. 2000; Neuronal plasticity: increasing the gain in pain. Science. 288:1765–9. DOI: 10.1126/science.288.5472.1765. PMID: 10846153.
Article
24. Geertzen JH, Dijkstra PU, Groothoff JW, ten Duis HJ, Eisma WH. 1998; Reflex sympathetic dystrophy of the upper extremity--a 5.5-year follow-up. Part I. Impairments and perceived disability. Acta Orthop Scand Suppl. 279:12–8. DOI: 10.1080/17453674.1998.11744781. PMID: 9614810.
25. Vaneker M, Wilder-Smith OH, Schrombges P, Oerlemans HM. 2006; Impairments as measured by ISS do not greatly change between one and eight years after CRPS 1 diagnosis. Eur J Pain. 10:639–44. DOI: 10.1016/j.ejpain.2005.10.003. PMID: 16300975.
Article
26. Miller MH, Topliss DJ. 1988; Chronic upper limb pain syndrome (repetitive strain injury) in the Australian workforce: a systematic cross sectional rheumatological study of 229 patients. J Rheumatol. 15:1705–12. PMID: 2976831.
27. Savaş S, Baloğlu HH, Ay G, Cerçi SS. 2009; The effect of sequel symptoms and signs of Complex Regional Pain Syndrome type 1 on upper extremity disability and quality of life. Rheumatol Int. 29:545–50. DOI: 10.1007/s00296-008-0748-8. PMID: 18953539.
Article
28. Kemler MA, de Vet HC. 2000; Health-related quality of life in chronic refractory reflex sympathetic dystrophy (complex regional pain syndrome type I). J Pain Symptom Manage. 20:68–76. DOI: 10.1016/S0885-3924(00)00170-6. PMID: 10946171.
Article
29. Kemler MA, Furnée CA. 2002; The impact of chronic pain on life in the household. J Pain Symptom Manage. 23:433–41. DOI: 10.1016/S0885-3924(02)00386-X. PMID: 12007761.
Article
30. DeGood DE, Cundiff GW, Adams LE, Shutty MS Jr. 1993; A psychosocial and behavioral comparison of reflex sympathetic dystrophy, low back pain, and headache patients. Pain. 54:317–22. DOI: 10.1016/0304-3959(93)90031-J. PMID: 8233546.
Article
31. Theadom A, Cropley M, Humphrey KL. 2007; Exploring the role of sleep and coping in quality of life in fibromyalgia. J Psychosom Res. 62:145–51. DOI: 10.1016/j.jpsychores.2006.09.013. PMID: 17270572.
Article
32. Kothari DJ, Davis MC, Yeung EW, Tennen HA. 2015; Positive affect and pain: mediators of the within-day relation linking sleep quality to activity interference in fibromyalgia. Pain. 156:540–6. DOI: 10.1097/01.j.pain.0000460324.18138.0a. PMID: 25679472. PMCID: PMC5538313.
33. Grandner MA, Chakravorty S, Perlis ML, Oliver L, Gurubhagavatula I. 2014; Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors. Sleep Med. 15:42–50. DOI: 10.1016/j.sleep.2013.09.012. PMID: 24333222. PMCID: PMC3947242.
Article
34. Liu Y, Wheaton AG, Chapman DP, Croft JB. 2013; Sleep duration and chronic diseases among U.S. adults age 45 years and older: evidence from the 2010 Behavioral Risk Factor Surveillance System. Sleep. 36:1421–7. DOI: 10.5665/sleep.3028. PMID: 24082301. PMCID: PMC3773191.
Article
35. Gallicchio L, Kalesan B. 2009; Sleep duration and mortality: a systematic review and meta-analysis. J Sleep Res. 18:148–58. DOI: 10.1111/j.1365-2869.2008.00732.x. PMID: 19645960.
Article
36. Zhai L, Zhang H, Zhang D. 2015; Sleep duration and depression among adults: a meta-analysis of prospective studies. Depress Anxiety. 32:664–70. DOI: 10.1002/da.22386. PMID: 26047492.
Article
37. Sharma A, Agarwal S, Broatch J, Raja SN. 2009; A web-based cross-sectional epidemiological survey of complex regional pain syndrome. Reg Anesth Pain Med. 34:110–5. DOI: 10.1097/AAP.0b013e3181958f90. PMID: 19282709.
Article
38. Sathvik BS, Parthasarathi G, Narahari MG, Gurudev KC. 2008; An assessment of the quality of life in hemodialysis patients using the WHOQOL-BREF questionnaire. Indian J Nephrol. 18:141–9. DOI: 10.4103/0971-4065.45288. PMID: 20142925. PMCID: PMC2813538.
Article
39. Chiu WT, Huang SJ, Hwang HF, Tsauo JY, Chen CF, Tsai SH, et al. 2006; Use of the WHOQOL-BREF for evaluating persons with traumatic brain injury. J Neurotrauma. 23:1609–20. DOI: 10.1089/neu.2006.23.1609. PMID: 17115908.
Article
40. Feldman SI, Downey G, Schaffer-Neitz R. 1999; Pain, negative mood, and perceived support in chronic pain patients: a daily diary study of people with reflex sympathetic dystrophy syndrome. J Consult Clin Psychol. 67:776–85. DOI: 10.1037/0022-006X.67.5.776. PMID: 10535244.
Article
41. Sandroni P, Benrud-Larson LM, McClelland RL, Low PA. 2003; Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain. 103:199–207. DOI: 10.1016/S0304-3959(03)00065-4. PMID: 12749974.
Article
42. Brunner F, Nauer M, Bachmann LM. 2011; Poor prognostic factors in complex regional pain syndrome 1: a Delphi survey. J Rehabil Med. 43:783–6. DOI: 10.2340/16501977-0856. PMID: 21874213.
Article
43. Lee DH, Noh EC, Kim YC, Hwang JY, Kim SN, Jang JH, et al. 2014; Risk factors for suicidal ideation among patients with complex regional pain syndrome. Psychiatry Investig. 11:32–8. DOI: 10.4306/pi.2014.11.1.32. PMID: 24605121. PMCID: PMC3942549.
Article
44. Lee SJ, Yoo YM, You JA, Shin SW, Kim TK, Abdi S, et al. 2019; Successful removal of permanent spinal cord stimulators in patients with complex regional pain syndrome after complete relief of pain. Korean J Pain. 32:47–50. DOI: 10.3344/kjp.2018.32.1.47. PMID: 30671203. PMCID: PMC6333578.
Article
Full Text Links
  • KJP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr