World J Mens Health.  2021 Jul;39(3):533-540. 10.5534/wjmh.200042.

Erectile Dysfunction in Germ Cell Tumor Survivors

• Okada K
• Fujita K
• Fukuhara S
• Kiuchi H
• Uemura M
• Imamura R
• Nonomura N

• KMID: 2516719
• DOI: http://doi.org/10.5534/wjmh.200042

Abstract

Purpose
Germ cell tumors (GCTs) are the most common malignant neoplasms in adolescents and young adults, and most patients with these tumors can be completely cured. Therefore, maintaining quality of life (QOL) is important. Erectile dysfunction (ED) is one factor that reduces the QOL of GCT survivors. We aimed to clarify the relationship between ED and age, follow-up period, serum levels of hormones, and treatment methods for GCT survivors.
Materials and Methods
We evaluated ED using the Sexual Health Inventory for Men questionnaire (SHIM) and measured serum levels of hormones in survivors after GCT treatment. The relationships between the SHIM score responses and age, serum levels of hormones, follow-up period, and treatment methods were assessed using a logistic analysis.
Results
Fifty-two GCT survivors were enrolled and 46 survivors completed the SHIM. The median age, follow-up period, and SHIM score were 38 years, 35 months, and 18, respectively. Regarding the SHIM scores, 85% had scores <22 and 46% had scores <17. The percentage of SHIM scores <17 was 69% in patients with under 2 years of follow-up. It significantly improved to 33% in patients with over 2 years of follow-up. The multivariate analysis identified the follow-up period as an independent factor for SHIM scores <17. Age, serum levels of hormone, and treatment method were not significant factors for SHIM scores <17.
Conclusions
Improvement of SHIM score can be expected after GCT treatment regardless of age, serum levels of hormone, and treatment method.

Keyword

Erectile dysfunction; Neoplasms; germ cell and embryonal; Sexual health; Survivors