World J Mens Health.
2021 Jul;39(3):516-525. 10.5534/wjmh.200070.
Combined Effects of the FSHR 2039 A/G and FSHR-29 G/A Polymorphisms on Male Reproductive Parameters
- Affiliations
-
- 1Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
- 2Department of Biomedical and Biotechnological Science, BIOMETEC, University of Catania, Catania, Italy
- 3Department of Biomedical and Biotechnological Science, BIOMETEC-Sect. of Microbiology, University of Catania, Catania, Italy
- KMID: 2516717
- DOI: http://doi.org/10.5534/wjmh.200070
Abstract
- Purpose
The aim of this study was to evaluate the combined effect of FSHR 2039 A/G and FSHR-29 G/A single nucleotide polymorphisms (SNPs) on the male reproductive function in a cohort of Sicilian men.
Materials and Methods
One-hundred thirty Sicilian men were enrolled and underwent blood withdrawal for hormone measurement and FSHR 2039 A/G and FSHR-29 G/A SNP genotyping, testicular volume evaluation by ultrasound scan, and semen analysis. A meta-analysis of the FSHR -29 G/A SNP, evaluated in a previous study of the Sicilian population was done.
Results
No genotype of the FSHR 2039 A/G SNP correlated with serum follicle-stimulating hormone (FSH) levels, testicular volume, sperm concentration, and total sperm count. In contrast, normozoospermic men with FSHR -29 GG and FSHR -29 GA genotypes had significantly lower sperm concentrations compared to men with the FSHR -29 AA genotype. The other sperm parameters did not show any significant difference. The meta-analysis showed no significant difference in serum FSH levels, testicular volume, sperm concentration, and total sperm count between FSHR -29 GG and FSHR -29 AA in Sicilian men. No difference was found even when the two SNPs were evaluated in combination. However, this combination was present, as expected, only in a low proportion (3.8%) of the men studied.
Conclusions
The SNPs FSHR 2039 A/G and FSHR -29 G/A in combination did not seem to have any effect on male reproductive function in a cohort of Sicilian men. The effect of these SNPs has only been studied in granulosa cells so far. Further studies on their role in Sertoli cells are needed.
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