Korean J Reprod Med.  2008 Mar;35(1):69-76.

Relationship between FSH Receptor Genotype and Clinical Outcomes of IVF-ET in Infertile Korean Women

• Moon MH
• Choi HW
• Kim MJ
• Lee HS
• Cha SH
• Song IO
• Koong MK
• Jun JH

Abstract

OBJECTIVE
The purposes of this study were to determine the distribution of follicle-stimulating hormone receptor (FSHR) genotypes in infertile Korean women and to evaluate the relationship between FSHR genotypes and clinical outcomes of IVF-ET cycles.
METHODS
Genomic DNA was extracted from peripheral blood in 1,020 of infertile Korean women. Genotypes of FSHR at Thr307Ala (T/A) and Asn680Ser (N/S) were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Clinical outcomes related to the genotypes of FSHR were evaluated in IVF-ET cycles (n=302) with controlled ovarian hyperstimulation (COH) of infertile women under 40 years old.
RESULTS
In a population of 1,020 infertile Korean women, the frequency of TT/NN, TA/NS and AA/SS for the major variant Thr307Ala and Asn680Ser was 44.80%, 41.96% and 10.49%, respectively. There was no significant difference in characteristics of ovarian response and clinical pregnancy rate among the major genotypes of FSHR in IVF-ET cycles with COH. However, implantation rate of AA/SS patients was significantly higher than that of TT/NN patients (24.5% vs 15.7%, p<0.05).
CONCLUSION
This study showed that FSHR genotype was not directly associated with ovarian response in IVF-ET cycles with COH. The relationship between clinical outcomes and FSHR genotypes of patients should be substantiated by further studies.

Keyword

Follicle-stimulating hormone receptor (FSHR); Genotype; Controlled ovarian hyperstimulation (COH); Ovarian response; Clinical outcome

MeSH Terms

DNA
Female
Genotype
Humans
Pregnancy Rate
Receptors, FSH
DNA
Receptors, FSH