Clin Exp Reprod Med.  2012 Dec;39(4):166-171. 10.5653/cerm.2012.39.4.166.

Comparison of assisted reproductive technology outcomes in infertile women with polycystic ovary syndrome: In vitro maturation, GnRH agonist, and GnRH antagonist cycles

• Choi MH
• Lee SH
• Kim HO
• Cha SH
• Kim JY
• Yang KM
• Song IO
• Koong MK
• Kang IS
• Park CW

• KMID: 1882022
• DOI: http://doi.org/10.5653/cerm.2012.39.4.166

Abstract

OBJECTIVE
We compared the assisted reproductive technology (ART) outcomes among infertile women with polycystic ovary syndrome (PCOS) treated with IVM, conventional IVF, GnRH agonist, and GnRH antagonist cycles.
METHODS
The prospective study included a total of 67 cycles in 61 infertile women with PCOS. The women with PCOS were randomized into three IVF protocols: IVM/IVF with FSH and hCG priming with immature oocyte retrieval 38 hours later (group A, 14 cycles), GnRH agonist long protocol (group B, 14 cycles), and GnRH antagonist multi-dose flexible protocol (group C, 39 cycles). IVF outcomes, such as clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR), were compared among the three groups.
RESULTS
Age, BMI, and basal FSH and LH levels did not differ among the three groups. The number of retrieved oocytes and 2 pronucleus embryos was significantly lower in group A compared with groups B and C. The CPR, IR, MR, and LBR per embryo transfer showed no differences among the three groups. There was no incidence of ovarian hyperstimulation syndrome in group A.
CONCLUSION
The IR, MR, and LBR in the IVM cycles were comparable to those of the GnRH agonist and GnRH antagonist cycles. The IVM protocol, FSH and hCG priming with oocyte retrieval 38 hours later, is an effective ART option that is comparable with conventional IVF for infertile women with PCOS.

Keyword

Polycystic ovary syndrome; In vitro maturation; GnRH antagonist; GnRH agonist; Assisted reproductive technology outcome

MeSH Terms

Abortion, Spontaneous
Cardiopulmonary Resuscitation
Embryo Transfer
Embryonic Structures
Female
Gonadotropin-Releasing Hormone
Humans
Incidence
Live Birth
Oocyte Retrieval
Oocytes
Ovarian Hyperstimulation Syndrome
Ovary
Polycystic Ovary Syndrome
Pregnancy
Pregnancy Rate
Prospective Studies
Reproductive Techniques, Assisted
Gonadotropin-Releasing Hormone