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IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa

Cannarella R, Condorelli RA, Vignera SL, Bellucci C, Luca G, Calafiore R, Calogero AE

Purpose: Oligozoospermia is highly prevalent worldwide. Studies have reported a lower methylation rate in the H19 differentially methylated region at the sperm level in oligozoospermic patients than in controls. IGF2/H19...
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Combined Effects of the FSHR 2039 A/G and FSHR-29 G/A Polymorphisms on Male Reproductive Parameters

Cannarella R, Musso N, Condorelli RA, Musmeci M, Stefani S, Vignera SL, Calogero AE

Purpose: The aim of this study was to evaluate the combined effect of FSHR 2039 A/G and FSHR-29 G/A single nucleotide polymorphisms (SNPs) on the male reproductive function in a...
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Analysis of 29 Targeted Genes for Non-Obstructive Azoospermia: The Relationship between Genetic Testing and Testicular Histology

Cannarella R, Bertelli M, Condorelli RA, Vilaj M, Vignera SL, Jezek D, Calogero AE

Purpose To analyze the presence of potentially pathogenic variants of 29 candidate genes known to cause spermatogenic failure (SPGF) in patients with non-obstructive azoospermia (NOA) who underwent testicular histology. Materials and Methods Forty-eight...
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Globozoospermia: A Case Report and Systematic Review of Literature

Crafa A, Condorelli RA, Vignera SL, Calogero AE, Cannarella R

Purpose: Globozoospermia is a genetic syndrome characterized by the presence of round-headed spermatozoa and infertility due to the inability of these spermatozoa to fertilize the oocyte. In this article, we...
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The Renaissance of Male Infertility Management in the Golden Age of Andrology

Calogero AE, Cannarella R, Agarwal A, Abdel-Meguid Hamoda TAA, Rambhatla A, Saleh R, Boitrelle F, Ziouziou I, Toprak T, Gul M, Avidor-Reiss T, Kavoussi P, Chung E, Birowo P, Ghayda RA, Ko E, Colpi G, Dimitriadis F, Russo GI, Martinez M, Calik G, Kandil H, Salvio G, Mostafa T, Lin H, Park HJ, Gherabi N, Vinh Phuoc NH, Quang N, Adriansjah R, Vignera SL, Micic S, Durairajanayagam D, Serefoglu EC, Karthikeyan VS, Kothari P, Atmoko W, Shah R

Infertility affects nearly 186 million people worldwide and the male partner is the cause in about half of the cases. Meta-regression data indicate an unexplained decline in sperm concentration and...
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