J Vet Sci.
2021 May;22(3):e33. 10.4142/jvs.2021.22.e33.
Dexamethasone reduces infectious bursal disease mortality in chickens
- Affiliations
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- 1Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- 2Farm Animal Clinical Training, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- 3Department of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- KMID: 2516205
- DOI: http://doi.org/10.4142/jvs.2021.22.e33
Abstract
- Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8–9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.
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