J Vet Sci.  2021 May;22(3):e33. 10.4142/jvs.2021.22.e33.

Dexamethasone reduces infectious bursal disease mortality in chickens

Affiliations
  • 1Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
  • 2Farm Animal Clinical Training, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
  • 3Department of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea

Abstract

Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8–9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.

Keyword

Very virulent infectious bursal disease virus; nitric oxide; bursa of Fabricius; bursa-to-body-weight ratio; aspirin; vitamin E; selenium
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