J Korean Soc Radiol.  2021 May;82(3):756-763. 10.3348/jksr.2020.0061.

Early and Atypical Radiologic Presentations of Pulmonary Langerhans Cell Histiocytosis: A Report of Two Cases

Affiliations
  • 1Departments of Radiology, Soonchunhyang University Seoul Hospital, Seoul, Korea
  • 2Departments of Pathology, Soonchunhyang University Seoul Hospital, Seoul, Korea
  • 3Departments of Cardiothoracic Surgery, Soonchunhyang University Seoul Hospital, Seoul, Korea
  • 4Departments of Nuclear Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea

Abstract

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, multi-systemic disease primarily affecting young male adults with a history of smoking. The two patients with PLCH in our report showed relatively early and atypical radiologic presentations at initial evaluation. On chest CT, PLCH presents variable radiologic features depending on the evolutional stage of the disease. Atypical CT features of PLCH may render precise radiologic diagnosis difficult and usually require lung biopsy for a confirmation of the diagnosis. Our case review is aimed at raising the awareness of radiologists on the atypical CT features of PLCH, to help make accurate radiologic diagnosis and prevent unnecessary and invasive diagnostic procedures.

Keyword

Histiocytosis; Langerhans-Cell; Lung; Tomography; X-Ray Computed; Radiography
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