Pediatr Infect Vaccine.  2021 Apr;28(1):7-20. 10.14776/piv.2021.28.e6.

Updates on Coronavirus Disease-2019 Vaccine and Consideration in Children

Affiliations
  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, the Republic of Korea
  • 2Department of Pediatrics, Seoul National University, College of Medicine, Seoul, the Republic of Korea
  • 3Department of Pediatrics, Seoul National University, College of Medicine, Seoul, the Republic of Korea
  • 4Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, the Republic of Korea

Abstract

As of March 2021, humanity has been suffering from the global severe acute respiratory syndrome coronavirus 2 pandemic that began late 2019. In 2020, new vaccine platforms— including mRNA vaccines and viral vector-based DNA vaccines—have been given emergency use authorization (EUA), leading to rolling out the vaccines for global mass vaccinations. The purpose of this article is to review the currently most widely used coronavirus disease 2019 vaccines: their action mechanisms and efficacy and safety data from clinical trials that have been published to date. In addition, the current status of clinical trials in the pediatric population was summarized, and further consideration for them was discussed.

Keyword

COVID-19; SARS-CoV-2; Vaccines; Child
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