J Korean Med Sci.  2021 Apr;36(15):e110. 10.3346/jkms.2021.36.e110.

Early Safety Monitoring of COVID-19 Vaccines in Healthcare Workers

Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
  • 2Department of Hospital Infection Control, Korea University Guro Hospital, Seoul, Korea
  • 3Department of Hospital Infection Control, Korea University Anam Hospital, Seoul, Korea
  • 4Department of Hospital Infection Control, Korea University Ansan Hospital, Ansan, Korea
  • 5Division of Infectious Diseases, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
  • 6Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea

Abstract

Hospital-based surveillance for adverse events was conducted on healthcare workers after they received the first dose of coronavirus disease 2019 (COVID-19) vaccine. Among the two new platform vaccines (messenger RNA- and adenoviral vector-based vaccines), the rates of systemic adverse events were significantly higher among adenovirus-vectored vaccine recipients. Fatigue (87.6% vs. 53.8%), myalgia (80.8% vs. 50.0%), headache (72.0% vs. 28.8%), and fever (≥ 38.0°C, 38.7% vs. 0%) were the most common adverse events among adenovirus-vectored vaccine recipients, but most symptoms resolved within 2 days. Both types of COVID-19 vaccines were generally safe, and serious adverse events rarely occurred.

Keyword

COVID-19; Vaccine; Safety; Adverse Event; Surveillance
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