J Korean Neurosurg Soc.  2021 Mar;64(2):309-315. 10.3340/jkns.2020.0040.

Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population

• Yang X
• Xu H
• Liu D
• Ma R
• Zhang Y
• Wang G

• KMID: 2513862
• DOI: http://doi.org/10.3340/jkns.2020.0040

Abstract

Objective
: To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region.
Methods
: This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed.
Results
: In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups.
Conclusion
: An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.

Keyword

Stroke; HDAC9 protein; Polymorphism

Reference

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