J Korean Neurosurg Soc.  2020 Sep;63(5):550-558. 10.3340/jkns.2019.0220.

The Correlation between E-Selectin S128R Gene Polymorphism and Ischemic Stroke in Chinese Population : A Meta-Analysis

• Yang X
• Ma R
• Zhang Y
• Wang G

• KMID: 2506018
• DOI: http://doi.org/10.3340/jkns.2019.0220

Abstract

To perform a systematic review of the data collected from case-control studies conducted earlier to investigate the correlation between E-selectin S128R polymorphism and ischemic stroke (IS) risk among the Chinese population. The PubMed, Web of Science, Chinese biomedical literature database (CBM), Chinese databases China National Knowledge Infrastructure (CNKI), WanfangData knowledge service platform (Wanfang Data), and information resource integration service platform (VIP) Databases were searched to retrieve case-control studies on the correlation between E-selectin gene S128R polymorphism and IS from the inception of the database till June 2019. The literature was screened, data were extracted, the risk of bias was reviewed, and the studies included were assessed independently by two reviewers. Stata ver. 12.0 software (Stata Corp LLC, College Station, TX, USA) was used to perform the meta-analysis. A total of 2907 cases from eight case-control studies involving 1478 IS patients and 1429 controls were included in this study. The R allele and RS genotype in E-selectin were found to be associated with the risk of IS as per the results of the meta-analysis (R vs. S : odds ratio [OR], 2.75; 95% confidence interval [CI], 2.15-3.51; p<0.00001; RS vs. SS : OR, 2.50; 95% CI, 1.95-3.19; p<0.00001; RR+RS vs. SS : OR, 2.85, 95% CI, 2.21-3.67; p<0.00001). The E-selectin gene S128R polymorphism is likely related to IS based on the results of a meta-analysis in the Chinese population, and the R allele and RS genotype of E-selectin may be IS risk factors.

Keyword

E-selectin; Polymorphism; Stroke; Meta-analysis

Figure

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  Fig. 1. Flowchart representing the article selection procedure for the meta-analysis of the correlation between E-selectin S128R polymorphism.

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  Fig. 2. Forest plot of IS risk associated with E-selectin S128R polymorphism. A : Allelic contrast model (R vs. S). b : Homozygote model (RR vs. SS). c : Heterozygote model (RS vs. SS). D : Dominant model (RR+RS vs. SS). E : Recessive model (RR vs. RS+SS). OR : odds ratio, M.H. : Mantel-Haenszel, cI : confidence interval, IS : ischemic stroke.

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  Fig. 3. Funnel plot for risk of IS associated with E-selectin S128R polymorphism. SE : standard error, OR : odds ratio; IS : ischemic stroke.

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  Fig. 4. Sensitivity analysis of OR summary on correlation between polymorphism of E-selectin S128Rand IS risk. A : Allelic contrast model (R vs. S). b : Homozygote model (RR vs. SS). c : Heterozygote model (RS vs. SS). D : Dominant model (RR+RS vs. SS). E : Recessive model (RR vs. RS+SS). OR : odds ratio, IS : ischemic stroke.

Reference

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