J Stroke.  2015 May;17(2):138-143. 10.5853/jos.2015.17.2.138.

Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis

• Kumar A
• Prasad M
• Kumar P
• Yadav AK
• Pandit AK
• Kathuria P

• KMID: 2223670
• DOI: http://doi.org/10.5853/jos.2015.17.2.138

Abstract

BACKGROUND AND PURPOSE
The purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (beta2AR) polymorphism and Ischemic stroke.
METHODS
Published case control studies on association between beta2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2.
RESULTS
A total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of beta2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of beta2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81).
CONCLUSIONS
The present meta-analysis suggests that Gln27Glu polymorphism of beta2AR gene is associated with increased risk for ischemic stroke.

Keyword

beta2-adrenergic receptor gene; beta2AR; Ischemic stroke; Cerebral infarction; Polymorphism; Meta-analysis

MeSH Terms

Alleles
Case-Control Studies
Cerebral Infarction
Humans
Odds Ratio
Receptors, Adrenergic*
Receptors, Adrenergic, beta-2
Stroke*
Receptors, Adrenergic
Receptors, Adrenergic, beta-2