J Korean Foot Ankle Soc.  2021 Mar;25(1):10-16. 10.14193/jkfas.2021.25.1.10.

How Effective Is the Injection Therapy in Foot and Ankle Disorder?

Affiliations
  • 1Department of Orthopedic Surgery, Bone Hospital, Jeonju, Korea

Abstract

Evidence-based papers on the treatment of some chronic tendinopathy or ligament lesions using an injection in foot and ankle disorders have been reported, but there are few reports on the treatment of acute ankle ligament injury. On the other hand, some papers have reported a faster return to play for injection therapy that combines RICE (Rest, Icing, Compression, and Elevation) treatment and rehabilitation. Injection therapy can be used as an additional treatment for ankle ligament injury. Rather than having narrow-minded thinking about these treatments, it is important to make efforts to verify the safety and precautions of treatment and recognize them as a category of normal treatment. Continuous analysis and monitoring of these treatments can satisfy patients whose needs are changing rapidly.

Keyword

Injection; Foot; Ankle; Ligament; Tendon

Cited by  1 articles

Hyaluronic Acid and Platelet-Rich Plasma Injections in Foot and Ankle Disorders
Gun-Woo Lee, Joonkyoo Kang
J Korean Foot Ankle Soc. 2023;27(3):79-86.    doi: 10.14193/jkfas.2023.27.3.79.


Reference

1. Saunders S, Longworth S, Maddison P. 2006. Injection techniques in orthopaedics and sports medicine: a practical manual for doctors and physiotherapists. 3rd ed. Elsevier/Churchill Livingstone;Edinburgh:
2. Johnson JE, Klein SE, Putnam RM. 2011; Corticosteroid injections in the treatment of foot & ankle disorders: an AOFAS survey. Foot Ankle Int. 32:394–9. doi: 10.3113/FAI.2011.0394. DOI: 10.3113/FAI.2011.0394. PMID: 21733442.
3. Grice J, Marsland D, Smith G, Calder J. 2017; Efficacy of foot and ankle corticosteroid injections. Foot Ankle Int. 38:8–13. doi: 10.1177/1071100716670160. DOI: 10.1177/1071100716670160. PMID: 27672014.
Article
4. Mansour AA, Porter DA, Young JP, Hammer D, Boublik M, Schlegel TF. 2013; Corticosteroid injections hasten return to play of National Football League players following stable ankle syndesmosis sprains. Orthop J Sports Med. 1(4 Suppl):2325967113S00023. doi: 10.1177/2325967113S00023. DOI: 10.1177/2325967113S00023. PMCID: PMC4588937.
Article
5. Forrester JV, Balazs EA. 1980; Inhibition of phagocytosis by high molecular weight hyaluronate. Immunology. 40:435–46. PMID: 7429537. PMCID: PMC1458049.
6. Cohen MM, Altman RD, Hollstrom R, Hollstrom C, Sun C, Gipson B. 2008; Safety and efficacy of intra-articular sodium hyaluronate (Hyalgan) in a randomized, double-blind study for osteoarthritis of the ankle. Foot Ankle Int. 29:657–63. doi: 10.3113/FAI.2008.0657. DOI: 10.3113/FAI.2008.0657. PMID: 18785414.
Article
7. Lee DH, Kim TH, Han SH. 2011; Efficacy of intra-articular hyaluronic acid injection in early stage ankle osteoarthritis. J Korean Foot Ankle Soc. 15:27–31.
8. Petrella MJ, Cogliano A, Petrella RJ. 2009; Original research: long-term efficacy and safety of periarticular hyaluronic acid in acute ankle sprain. Phys Sportsmed. 37:64–70. doi: 10.3810/psm.2009.04.1684. DOI: 10.3810/PSM.2009.04.1684. PMID: 20048489.
Article
9. Suh DS, Lee JK, Yoo JC, Woo SH, Kim GR, Kim JW, et al. 2017; Atelocollagen enhances the healing of rotator cuff tendon in rabbit model. Am J Sports Med. 45:2019–27. doi: 10.1177/0363546517703336. DOI: 10.1177/0363546517703336. PMID: 28586622.
Article
10. Seong H, Kim RK, Shin Y, Lee HW, Koh JC. 2020; Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain. Korean J Pain. 33:395–9. doi: 10.3344/kjp.2020.33.4.395. DOI: 10.3344/kjp.2020.33.4.395. PMID: 32989204. PMCID: PMC7532294.
Article
11. Kim IB, Kim EY, Lim KP, Heo KS. 2019; Does the use of injectable atelocollagen during arthroscopic rotator cuff repair improve clinical and structural outcomes? Clin Shoulder Elb. 22:183–9. doi: 10.5397/cise.2019.22.4.183. DOI: 10.5397/cise.2019.22.4.183. PMID: 33330217. PMCID: PMC7714314.
Article
12. Jin SH, Kim WJ, Park HS, Kim CH, Chung RK, Baik HJ, et al. 2019; The effect of atelocollagen on the treatment of chronic anterior talofibular ligament tear: a case report. Int J Pain. 10:10–6.
13. Cronstein BN. 1994; Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol (1985). 76:5–13. doi: 10.1152/jappl.1994.76.1.5. DOI: 10.1152/jappl.1994.76.1.5. PMID: 8175547.
Article
14. Polito F, Bitto A, Galeano M, Irrera N, Marini H, Calò M, et al. 2012; Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps. J Vasc Surg. 55:479–88. doi: 10.1016/j.jvs.2011.07.083. DOI: 10.1016/j.jvs.2011.07.083. PMID: 22051873.
Article
15. Altavilla D, Bitto A, Polito F, Marini H, Minutoli L, Di Stefano V, et al. 2009; Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovasc Hematol Agents Med Chem. 7:313–21. doi: 10.2174/187152509789541909. DOI: 10.2174/187152509789541909. PMID: 19860658.
Article
16. Hirose K, Kondo S, Choi HR, Mishima S, Iwata H, Ishiguro N. 2004; Spontaneous healing process of a supraspinatus tendon tear in rabbits. Arch Orthop Trauma Surg. 124:374–7. doi: 10.1007/s00402-004-0663-8. DOI: 10.1007/s00402-004-0663-8. PMID: 15156330.
Article
17. Kim JY, Pak CS, Park JH, Jeong JH, Heo CY. 2014; Effects of polydeoxyribonucleotide in the treatment of pressure ulcers. J Korean Med Sci. 29(Suppl 3):S222–7. doi: 10.3346/jkms.2014.29.S3.S222. DOI: 10.3346/jkms.2014.29.S3.S222. PMID: 25473213. PMCID: PMC4248009.
Article
18. Bitto A, Polito F, Irrera N, D'Ascola A, Avenoso A, Nastasi G, et al. 2011; Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A(2A) receptor. Arthritis Rheum. 63:3364–71. doi: 10.1002/art.30538. DOI: 10.1002/art.30538. PMID: 21769841.
Article
19. Do HK, Lee JH, Lim JY. 2018; Polydeoxyribonucleotide injection in the patients with partial-thickness tear of supraspinatus tendon: a prospective and pilot study using ultrasound. Phys Sportsmed. 46:213–20. doi: 10.1080/00913847.2018.1450059. DOI: 10.1080/00913847.2018.1450059. PMID: 29533161.
Article
20. Ryu K, Ko D, Lim G, Kim E, Lee SH. 2018; Ultrasound-guided prolotherapy with polydeoxyribonucleotide for painful rotator cuff tendinopathy. Pain Res Manag. 2018:8286190. doi: 10.1155/2018/8286190. DOI: 10.1155/2018/8286190. PMID: 29770163. PMCID: PMC5889899.
Article
21. Kim JK, Chung JY. 2015; Effectiveness of polydeoxyribonucleotide injection versus normal saline injection for treatment of chronic plantar fasciitis: a prospective randomised clinical trial. Int Orthop. 39:1329–34. doi: 10.1007/s00264-015-2772-0. DOI: 10.1007/s00264-015-2772-0. PMID: 25920599.
Article
22. Jo CH, Shin JS, Lee YG, Shin WH, Kim H, Lee SY, et al. 2013; Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears: a randomized, single-blind, parallel-group trial. Am J Sports Med. 41:2240–8. doi: 10.1177/0363546513497925. DOI: 10.1177/0363546513497925. PMID: 23921338.
23. Lebiedziński R, Synder M, Buchcic P, Polguj M, Grzegorzewski A, Sibiński M. 2015; A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis. Int Orthop. 39:2199–203. doi: 10.1007/s00264-015-2861-0. DOI: 10.1007/s00264-015-2861-0. PMID: 26224613.
Article
24. Bubnov R, Yevseenko V, Semeniv I. 2013; Ultrasound guided injections of platelets rich plasma for muscle injury in professional athletes. Comparative study. Med Ultrason. 15:101–5. doi: 10.11152/mu.2013.2066.152.rb1vy2. DOI: 10.11152/mu.2013.2066.152.rb1vy2. PMID: 23702498.
Article
25. Podesta L, Crow SA, Volkmer D, Bert T, Yocum LA. 2013; Treatment of partial ulnar collateral ligament tears in the elbow with platelet-rich plasma. Am J Sports Med. 41:1689–94. doi: 10.1177/0363546513487979. DOI: 10.1177/0363546513487979. PMID: 23666850.
Article
26. Creaney L, Hamilton B. 2008; Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med. 42:314–20. doi: 10.1136/bjsm.2007.040071. DOI: 10.1136/bjsm.2007.040071. PMID: 17984193.
Article
27. Geaney LE, Arciero RA, DeBerardino TM, Mazzocca AD. 2011; The effects of platelet-rich plasma on tendon and ligament: basic science and clinical application. Oper Tech Sports Med. 19:160–4. doi: 10.1053/j.otsm.2011.04.001. DOI: 10.1053/j.otsm.2011.04.001.
Article
28. Salamanna F, Veronesi F, Maglio M, Della Bella E, Sartori M, Fini M. 2015; New and emerging strategies in platelet-rich plasma application in musculoskeletal regenerative procedures: general overview on still open questions and outlook. Biomed Res Int. 2015:846045. doi: 10.1155/2015/846045. DOI: 10.1155/2015/846045. PMID: 26075269. PMCID: PMC4436449.
Article
29. Amar E, Snir N, Sher O, Brosh T, Khashan M, Salai M, et al. 2015; Platelet-rich plasma did not improve early healing of medial collateral ligament in rats. Arch Orthop Trauma Surg. 135:1571–7. doi: 10.1007/s00402-015-2306-7. DOI: 10.1007/s00402-015-2306-7. PMID: 26298561.
Article
30. Blanco-Rivera J, Elizondo-Rodríguez J, Simental-Mendía M, Vilchez-Cavazos F, Peña-Martínez VM, Acosta-Olivo C. 2020; Treatment of lateral ankle sprain with platelet-rich plasma: a randomized clinical study. Foot Ankle Surg. 26:750–4. doi: 10.1016/j.fas.2019.09.004. DOI: 10.1016/j.fas.2019.09.004. PMID: 31640921.
Article
31. Rowden A, Dominici P, D'Orazio J, Manur R, Deitch K, Simpson S, et al. 2015; Double-blind, randomized, placebo-controlled study evaluating the use of platelet-rich plasma therapy (PRP) for acute ankle sprains in the emergency department. J Emerg Med. 49:546–51. doi: 10.1016/j.jemermed.2015.03.021. DOI: 10.1016/j.jemermed.2015.03.021. PMID: 26048069.
Article
32. Laver L, Carmont MR, McConkey MO, Palmanovich E, Yaacobi E, Mann G, et al. 2015; Plasma rich in growth factors (PRGF) as a treatment for high ankle sprain in elite athletes: a randomized control trial. Knee Surg Sports Traumatol Arthrosc. 23:3383–92. doi: 10.1007/s00167-014-3119-x. DOI: 10.1007/s00167-014-3119-x. PMID: 24938396.
Article
33. Le ADK, Enweze L, DeBaun MR, Dragoo JL. 2018; Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med. 11:624–34. doi: 10.1007/s12178-018-9527-7. DOI: 10.1007/s12178-018-9527-7. PMID: 30353479. PMCID: PMC6220007.
Article
34. Moon SH, Lee S, Bae DK. 2018; Prolotherapy. J Korean Orthop Assoc. 53:393–9. doi: 10.4055/jkoa.2018.53.5.393. DOI: 10.4055/jkoa.2018.53.5.393. PMID: 28484944.
Article
35. Scarpone M, Rabago DP, Zgierska A, Arbogast G, Snell E. 2008; The efficacy of prolotherapy for lateral epicondylosis: a pilot study. Clin J Sport Med. 18:248–54. doi: 10.1097/JSM.0b013e318170fc87. DOI: 10.1097/JSM.0b013e318170fc87. PMID: 18469566. PMCID: PMC2751593.
Article
36. Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, et al. 2013; Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil. 92:587–96. doi: 10.1097/PHM.0b013e31827d695f. DOI: 10.1097/PHM.0b013e31827d695f. PMID: 23291605. PMCID: PMC3700532.
37. Maxwell NJ, Ryan MB, Taunton JE, Gillies JH, Wong AD. 2007; Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon: a pilot study. AJR Am J Roentgenol. 189:W215–20. doi: 10.2214/AJR.06.1158. DOI: 10.2214/AJR.06.1158. PMID: 17885034.
Article
38. Yelland MJ, Sweeting KR, Lyftogt JA, Ng SK, Scuffham PA, Evans KA. 2011; Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial. Br J Sports Med. 45:421–8. doi: 10.1136/bjsm.2009.057968. DOI: 10.1136/bjsm.2009.057968. PMID: 19549615.
Article
39. Ryan MB, Wong AD, Gillies JH, Wong J, Taunton JE. 2009; Sonographically guided intratendinous injections of hyperosmolar dextrose/lidocaine: a pilot study for the treatment of chronic plantar fasciitis. Br J Sports Med. 43:303–6. doi: 10.1136/bjsm.2008.050021. DOI: 10.1136/bjsm.2008.050021. PMID: 19019908.
Article
40. Morath O, Kubosch EJ, Taeymans J, Zwingmann J, Konstantinidis L, Südkamp NP, et al. 2018; The effect of sclerotherapy and prolotherapy on chronic painful Achilles tendinopathy-a systematic review including meta-analysis. Scand J Med Sci Sports. 28:4–15. doi: 10.1111/sms.12898. DOI: 10.1111/sms.12898. PMID: 28449312.
Article
41. Trescot A, Brown M. 2015; Peripheral nerve entrapment, hydrodissection, and neural regenerative strategies. Tech Reg Anesth Pain Manag. 19:85–93. doi: 10.1053/j.trap.2016.09.015. DOI: 10.1053/j.trap.2016.09.015.
Article
42. Lyftogt J. 2007; Subcutaneous prolotherapy treatment of refractory knee, shoulder, and lateral elbow pain. Australas Musculoskelet Med. 12:110–2.
Full Text Links
  • JKFAS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr