Immune Netw.
2021 Feb;21(1):e4. 10.4110/in.2021.21.e4.
Current Status of COVID-19 Vaccine Development: Focusing on Antigen Design and Clinical Trials on Later Stages
- Affiliations
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- 1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
- 2Department of Bioscience, University of Science and Technology (UST), Daejeon 34113, Korea
- 3Department of Biochemistry, Chungnam National University, Daejeon 34134, Korea
- 4International Vaccine Institute, Seoul 08826, Korea
- KMID: 2513570
- DOI: http://doi.org/10.4110/in.2021.21.e4
Abstract
- The global outbreak of coronavirus disease 2019 (COVID-19) is still threatening human health, economy, and social life worldwide. As a counteraction for this devastating disease, a number of vaccines are being developed with unprecedented speed combined with new technologies. As COVID-19 vaccines are being developed in the absence of a licensed human coronavirus vaccine, there remain further questions regarding the long-term efficacy and safety of the vaccines, as well as immunological mechanisms in depth. This review article discusses the current status of COVID-19 vaccine development, mainly focusing on antigen design, clinical trials in later stages, and immunological considerations for further study.
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