Clin Exp Vaccine Res.  2021 May;10(2):154-170. 10.7774/cevr.2021.10.2.154.

Inside the story about the research and development of COVID-19 vaccines

• Patel SP
• Patel GS
• Suthar JV

• KMID: 2525806
• DOI: http://doi.org/10.7774/cevr.2021.10.2.154

Abstract

The ongoing coronavirus threat from China has spread rapidly to other nations and has been declared a global health emergency by the World Health Organization (WHO). The pandemic has resulted in over half of the world's population living under conditions of lockdown. Several academic institutions and pharmaceutical companies that are in different stages of development have plunged into the vaccine development race against coronavirus disease 2019 (COVID-19). The demand for immediate therapy and potential prevention of COVID-19 is growing with the increase in the number of individuals affected due to the seriousness of the disease, global dissemination, lack of prophylactics, and therapeutics. The challenging part is a need for vigorous testing for immunogenicity, safety, efficacy, and level of protection conferred in the hosts for the vaccines. As the world responds to the COVID-19 pandemic, we face the challenge of an overabundance of information related to the virus. Inaccurate information and myths spread widely and at speed, making it more difficult for the public to identify verified facts and advice from trusted sources, such as their local health authority or WHO. This review focuses on types of vaccine candidates against COVID-19 in clinical as well as in the preclinical development platform.

Keyword

COVID-19; Vaccine; SARS-CoV-2; Clinical trials; Vaccine development; Vaccine candidate