Korean J Dermatol.  2021 Feb;59(2):94-99.

Clinical Characteristics of Psoriasis Patients with Elevated Total Serum Immunoglobulin E Levels: A Retrospective Single-Center Study

• Seok SH
• Im TB
• Shin JU
• Lee HJ
• Yoon MS
• Kim DH

Abstract

Background
Psoriasis is a chronic T17 cell-driven immune-mediated inflammatory disease. However, patients with psoriasis may have elevated total serum immunoglobulin E (IgE) levels, which is a hallmark of Th2 inflammation. In previous case reports, psoriasis patients with elevated total serum IgE levels did not respond well to treatment or had exacerbated eczema lesions.
Objective
We sought to investigate the clinical characteristics of psoriasis patients with elevated total serum IgE levels.
Methods
This is a retrospective chart review of 130 patients with psoriasis who were tested for total serum IgE levels from November 1, 2009, to October 31, 2019. We compared the demographics, clinical characteristics, disease severity, and treatment regimen for each elevated IgE group (＞214 U/mL) and normal IgE group (≤214 U/mL).
Results
Among 130 patients with psoriasis, 41 (31.5%) had elevated total serum IgE levels. Elevated total serum IgE levels were positively associated with the severity of disease; psoriasis lesions including those on the scalp, hands, feet, and flexures, which are difficult to treat, were observed to be significantly higher in patients with elevated total serum IgE levels. There was no correlation between age, sex, disease duration, or presence of pruritus and total serum IgE levels.
Conclusion
This study identified the clinical characteristics of psoriasis patients with elevated total serum IgE levels in Korea.

Keyword

Immunoglobulin E; Psoriasis