Clin Psychopharmacol Neurosci.
2021 Feb;19(1):174-178. 10.9758/cpn.2021.19.1.174.
Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases
- Berardis DD
1,2 - Rapini G1
- Olivieri L1
- Giardini A1
- Lauretis ID1
- Serroni N1
- Orsolini L3
- Fornaro M4
- Iasevoli F4
- Trotta S5
- Cottura P6
- Vellante F2
- Alessandrini M2
- Giannantonio MD2
- Affiliations
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- 1National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy
- 2Department of Neurosciences and Imaging, Chair of Psychiatry, University “G. d’Annunzio,” Chieti, Italy
- 3School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK
- 4Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University School of Medicine “Federico II,” Naples, Italy
- 5National Health Service, Department of Mental Health, Pescara, Italy
- 6National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Cuneo, Italy
- KMID: 2513405
- DOI: http://doi.org/10.9758/cpn.2021.19.1.174
Abstract
- Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2 /D3 receptors with preferential binding to the D 3 receptor, antagonism of 5HT2B receptors, and partial agonism of 5HT1A . Currently, cariprazine has shown clinical efficacy in patients with schizophrenia and with bipolar disorder, as well as adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. In the present case series, we report on two patients with treatment-resistant schizophrenia and partial response to clozapine who benefit from combination with cariprazine. The effects of cariprazine combination were remarkable also concerning the adverse metabolic effects of clozapine.
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