J Korean Soc Biol Ther Psychiatry.  2021 Feb;27(1):67-73.

Structural Changes in the Hippocampal Subfields in Early-Onset Mild Cognitive Impairment

  • 1Department of Psychiatry, Research Institute of Medical Science, Konkuk University Medical School, Chungju, korea
  • 2Department of Psychiatry, Konkuk University Chungju Hospital, Konkuk University Medical School, Chungju, korea


:The aim of this study was to examine the structural change in the hippocampal subfields in early-onset (EO) mild cognitive impairment (MCI) patients associated with the APOE ε4 carrier state.
:This study had 50 subjects aged 55-63 years, all of whom were diagnosed with amnestic MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K). The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The volumes of hippocampal subfields were measured for all the subjects. The calculations were based on the change of the volumes between the 2-year-interval brain Magnetic resonance image (MRI) scans between MCIcont and ADconv groups according to the Apolipoprotein ε4 (APOE ε4) carrier state.
:There was a significant correlation between APOE ε4 allele and structural changes in several hippocampal subfields. The volume reduction in cornus ammonis 1 (CA1) field and subiculum, especially in the APOE ε4 carriers. The significance was more prominent in ADconv group.
:These results suggest that the possession of APOE ε4 allele may lead to significantly greater predilection for the structural changes in hippocampal subfields, showing significant changes, especially in the ADconv patients compared with MCIcont patients.


Early-onset; Mild cognitive impairment; Hippocampus; APOE ε4; Atrophy.
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