Diabetes Metab J.  2020 Dec;44(6):840-841. 10.4093/dmj.2020.0252.

The Anti-Diabetic Drug Metformin from the Neuropathy Perspective

• Won JC

• KMID: 2513047
• DOI: http://doi.org/10.4093/dmj.2020.0252

Reference

1. Won J, Kwon H, Kim C, Lee J, Park T, Ko K, Cha B. Prevalence and clinical characteristics of diabetic peripheral neuropathy in hospital patients with type 2 diabetes in Korea. Diabetic Med. 2012; 29:e290–6.

2. American Diabetes Association. 11. Microvascular complications and foot care: standards of medical care in diabetes-2020. Diabetes Care. 2020; 43(Suppl 1):S135–51.

3. Kim SH, Park TS, Jin HY. Metformin preserves peripheral nerve damage with comparable effects to alpha lipoic acid in streptozotocin/high-fat diet induced diabetic rats. Diabetes Metab J. 2020; 44:842–53.

4. Cryer PE. Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721. Diabetologia. 2007; 50:222–4.

5. Tomkin GH. Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin. Br Med J. 1973; 3:673–5.

6. Wile DJ, Toth C. Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care. 2010; 33:156–61.

7. Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol. 2016; 17:44.

8. Ji RR, Gereau RW 4th, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev. 2009; 60:135–48.

9. Shiers S, Pradhan G, Mwirigi J, Mejia G, Ahmad A, Kroener S, Price T. Neuropathic pain creates an enduring prefrontal cortex dysfunction corrected by the type II diabetic drug metformin but not by gabapentin. J Neurosci. 2018; 38:7337–50.

10. Los DB, de Oliveira WH, Duarte-Silva E, Sougey WWD, de Freitas EdSR, de Oliveira AGV, Braga CF, de Franca MER, da Rocha Araujo SM, Rodrigues GB, Rocha SWS, Peixoto CA, de Moraes SRA. Preventive role of metformin on peripheral neuropathy induced by diabetes. Int Immunopharmacol. 2019; 74:105672.