J Bacteriol Virol.  2020 Sep;50(3):181-186. 10.4167/jbv.2020.50.3.181.

A Review of HPV Prevalence Research

• Seong J
• Ryou S
• Choi BS

• KMID: 2512137
• DOI: http://doi.org/10.4167/jbv.2020.50.3.181

Abstract

Human papillomavirus is known to be a major cause of cervical cancer. More than 190 HPV genotypes have been identified and classified into a high-risk group (18 genotypes) and a low-risk group (12 genotypes) depending on the risk of disease progression. This report investigated the results of domestic and overseas studies on HPV prevalence and genotype distribution; identified prevalence and genotype distribution in Korea and in the world; and described and presented the results obtained as part of an internal research project at the KNIH. Through systematic review and meta-analysis, the previous study shows that the prevalence of HPV was found to be 10.7% (worldwide) and 13.6% (Korea and China) in women with normal cytology, respectively. HPV-16, HPV-18, HPV-31, HPV-58, and HPV-52 were the five most prevalent genotypes in the world. By contrast, in East Asia, including Korea, HPV-16, HPV-18, HPV-58, HPV-52, and HPV-70 were the prevalent genotypes. In an intramural research project conducted by the KNIH, the prevalence of HPV was estimated to be about 36% according to a meta-analysis. This result provides the basic statistics of HPV infection in Korea.

Keyword

HPV; Prevalence; Meta-analysis

Figure

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  Fig. 1 Adjusted HPV prevalence in the world and Asia (Meta-analysis) (de Sanjosé, S., et al. The Lancet Infectious Diseases, 2007).

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  Fig. 2 Flow diagram for systematic review.

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  Fig. 3 HPV prevalence in Korea (Meta-analysis).

Reference

1. Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health 2020;8:e191-e203.DOI: 10.1016/S2214-109X(19)30482-6.

2. Korea Central Cancer Registry. Annual report of cancer statistics in Korea in 2015. 2017.

3. Statistics Korea. Statistics of reasons for death [Internet] [May 29, 2018]. Available from: http://kosis.kr/statisticsList/ statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01#SelectStatsBoxDiv.

4. Statistics Korea. National Health Insurance Corporation [Internet] [cited 2018 June 1]. Available from: http://kosis.kr/ statHtml/statHtml.do?orgId=350&tblId=TX_35001_A061&conn_path=I2.

5. de Sanjosé S, Brotons M, Pavón MA. The natural history of human papillomavirus infection. Best Pract Res Clin Obstet Gynaecol 2018;47:2-13.DOI: 10.1016/j.bpobgyn.2017.08.015. PMID: 28964706.

6. Lee EH, Um TH, Chi HS, Hong YJ, Cha YJ. Prevalence and Distribution of Human Papillomavirus Infection in Korean Women as Determined by Restriction Fragment Mass Polymorphism Assay. J Korean Med Sci 2012;27:1091-7.DOI: 10.3346/jkms.2012.27.9.1091. PMID: 22969258. PMCID: PMC3429829.

7. Zhou C, Tuong ZK, Frazer IH. Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System. Front Oncol 2019;9:682.DOI: 10.3389/fonc.2019.00682. PMID: 31428574. PMCID: PMC6688195.

8. Crow JM. Hpv: The Global Burden. Nature 2012;488:S2-3.DOI: 10.1038/488S2a. PMID: 22932437.

9. Munñz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27.DOI: 10.1056/NEJMoa021641. PMID: 12571259.

10. Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC. Human papillomavirus and cervical cancer. Lancet 2013; 382:889-99.DOI: 10.1016/S0140-6736(13)60022-7.

11. de Sanjosé S, Diaz M, Castellsagué X, Clifford G, Bruni L, Muñoz N, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007;7:453-9.DOI: 10.1016/S1473-3099(07)70158-5.

12. Albero G B-RL, Bosch FX, Bruni L, de Sanjosé S, Gómez D, Mena M, et al. Human Papillomavirus and Related Diseases Report. 2019.

13. Ogembo RK, Gona PN, Seymour AJ, Park HS, Bain PA, Maranda L, et al. Prevalence of human papillomavirus genotypes among African women with normal cervical cytology and neoplasia: a systematic review and meta- analysis. PLoS One 2015;10:e0122488.DOI: 10.1371/journal.pone.0122488. PMID: 25875167. PMCID: PMC4396854.