J Bacteriol Virol.  2020 Sep;50(3):181-186. 10.4167/jbv.2020.50.3.181.

A Review of HPV Prevalence Research

Affiliations
  • 1Division of Viral Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju 28159, Republic of Korea

Abstract

Human papillomavirus is known to be a major cause of cervical cancer. More than 190 HPV genotypes have been identified and classified into a high-risk group (18 genotypes) and a low-risk group (12 genotypes) depending on the risk of disease progression. This report investigated the results of domestic and overseas studies on HPV prevalence and genotype distribution; identified prevalence and genotype distribution in Korea and in the world; and described and presented the results obtained as part of an internal research project at the KNIH. Through systematic review and meta-analysis, the previous study shows that the prevalence of HPV was found to be 10.7% (worldwide) and 13.6% (Korea and China) in women with normal cytology, respectively. HPV-16, HPV-18, HPV-31, HPV-58, and HPV-52 were the five most prevalent genotypes in the world. By contrast, in East Asia, including Korea, HPV-16, HPV-18, HPV-58, HPV-52, and HPV-70 were the prevalent genotypes. In an intramural research project conducted by the KNIH, the prevalence of HPV was estimated to be about 36% according to a meta-analysis. This result provides the basic statistics of HPV infection in Korea.

Keyword

HPV; Prevalence; Meta-analysis

Figure

  • Fig. 1 Adjusted HPV prevalence in the world and Asia (Meta-analysis) (de Sanjosé, S., et al. The Lancet Infectious Diseases, 2007).

  • Fig. 2 Flow diagram for systematic review.

  • Fig. 3 HPV prevalence in Korea (Meta-analysis).


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