Clin Exp Vaccine Res.
2020 Jul;9(2):179-182. 10.7774/cevr.2020.9.2.179.
Current national policies for infant universal bacille CalmetteGuérin vaccination were associated with lower mortality from coronavirus disease 2019
- Affiliations
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- 1Laboratory of Molecular Immunology, Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- 2Department of Pulmonology, Yokohama City University School of Medicine, Yokohama, Japan
- 3Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
- KMID: 2511709
- DOI: http://doi.org/10.7774/cevr.2020.9.2.179
Abstract
- An exciting debate has emerged whether bacille Calmette-Guérin (BCG) vaccination is effective for the coronavirus disease 2019 (COVID-19) pandemic. Some advocated that BCGvaccinated people are less suffered from the virus because BCG vaccination is recommendedin COVID-19 high burden countries. However, the others objected because this seemingly attractive relationship is explainable with confounding factors. In a multiple regression with 171 countries adjusting socioeconomical and climatic covariates, countries with current universal pediatric BCG policy were associated with 30-fold (95% confidence interval, 17–52) decrease of COVID-19 mortality per population compared to countries without the policy.
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