Clin Exp Vaccine Res.
2020 Jul;9(2):159-163. 10.7774/cevr.2020.9.2.159.
Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
- Affiliations
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- 1LAQUIMAP, Dto. Química Orgánica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
- 2Laboratorio de Inmunología Experimental, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
- 3Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe, Argentina.
- KMID: 2511705
- DOI: http://doi.org/10.7774/cevr.2020.9.2.159
Abstract
- The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming Gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
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