Ann Clin Neurophysiol.  2020 Oct;22(2):129-130. 10.14253/acn.2020.22.2.129.

What is chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids?

• Kim BJ
• Park KM

• KMID: 2511091
• DOI: http://doi.org/10.14253/acn.2020.22.2.129

Keyword

Diplopia; Inflammation; Pons

Figure

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  Fig. 1. FLAIR axial (A, D) and gadolinium-enhanced T1-weighted coronal (B, E) and sagittal (C, F) brain magnetic resonance imaging (MRI). Initial MRI revealed foci of gadolinium enhancement with a punctate and curvilinear pattern, predominantly in the pons (arrows). Follow-up MRI performed 4 months after steroid therapy revealed a marked reduction in the extent of gadolinium-enhanced lesions.

Reference

1. Pittock SJ, Debruyne J, Krecke KN, Giannini C, van den Ameele J, De Herdt V, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 2010; 133:2626–2634.

2. Dudesek A, Rimmele F, Tesar S, Kolbaske S, Rommer PS, Benecke R, et al. CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 2014; 175:385–396.

3. Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, et al. Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 2017; 140:2415–2425.