Ann Clin Neurophysiol.  2020 Oct;22(2):112-116. 10.14253/acn.2020.22.2.112.

Overlap syndrome of Miller-Fisher syndrome/Pharyngeal-Cervical-Brachial variant-Guillain Barre Syndrome with anti-ganglioside complex antibodies

• Lee Sy
• Oh Si
• Huh SY
• Shin KJ
• Kim JK
• Yoon BA

• KMID: 2511087
• DOI: http://doi.org/10.14253/acn.2020.22.2.112

Abstract

Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) can present with overlapping features. A 56-year-old female developed ptosis and diplopia after an upper respiratory infection, and presented with facial palsy, dysarthria, brachial weakness, ataxia, and areflexia. Mild weakness of both legs appeared after a few days. Anti-ganglioside complex antibody were positive to IgG GM1/GQ1b and GQ1b/sulfatide antibodies. The present case suggests that the manifestation of overlap between MFS/PCB variants and GBS could be caused by antiganglioside complex antibodies.

Keyword

Guillain-Barré syndrome; Miller Fisher syndrome; Pharyngeal-cervical-brachial variant; Antibodies; Ganglioside; Anti-ganglioside complex

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