Ann Pediatr Endocrinol Metab.  2020 Dec;25(4):227-233. 10.6065/apem.2040002.001.

Comparison of different criteria for the definition of insulin resistance and its relationship to metabolic risk in children and adolescents

• Lee SH
• Ahn MB
• Choi YJ
• Kim SK
• Kim SH
• Cho WK
• Cho KS
• Suh BK
• Jung MH

• KMID: 2510893
• DOI: http://doi.org/10.6065/apem.2040002.001

Abstract

Purpose
Childhood obesity frequently persists into adulthood and is associated with insulin resistance (IR) and increased long-term morbidity and mortality. We compared IR criteria concerning 'age-specific cutoff point' (ACOP) and ‘fixed cutoff point’ (FCOP) for the identification of IR and investigated their correlation with metabolic syndrome (MS).
Methods
Data were acquired from the 5th Korea National Health and Nutrition Examination Survey (2010–2011). Participants ranged from 10 to 17 years of age and underwent fasting plasma glucose, insulin concentration, and lipid panel measurements. High fasting plasma insulin levels or increased homeostatic model assessment insulin resistance (HOMA-IR) were defined as IR. We analyzed MS and IR frequencies according to FCOP or ACOP.
Results
Among 719 participants, 165 (22.9%) were overweight or obese based on their body mass index. We found no prevalence of MS in underweight/normal weight participants and 12.7% prevalence rate in overweight or obese participants. IR according to ACOP was more closely associated with MS than IR according to FCOP. No differences were found in predicting the frequency of MS using FCOP or ACOP in both fasting plasma insulin and HOMA-IR.
Conclusion
The frequency of MS in participants with IR defined using ACOP and FCOP was similar. However, IR using ACOP was more closely associated with MS than IR using FCOP.

Keyword

Obesity; Insulin resistance; Metabolic syndrome; Child; Adolescents

Reference

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