Lab Anim Res.  2020 Mar;36(1):11-19. 10.1186/s42826-019-0032-y.

Characterization and applications of chimeric mice with humanized livers for preclinical drug development

• Tateno C
• Kojima Y

• KMID: 2510419
• DOI: http://doi.org/10.1186/s42826-019-0032-y

Abstract

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for clients weekly for in vitro studies. In this review, we summarize the existing characterizations of PXB-mice and PXB-cells and their present and future applications.

Keyword

Chimeric mice; Human hepatocytes; DMPK; HBV; HCV; Toxicology