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Characterization and applications of chimeric mice with humanized livers for preclinical drug development

Tateno C, Kojima Y

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice...
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Benefits and risks of diverting stoma creation during rectal cancer surgery

Kawai M, Sakamoto K, Honjo K, Okazawa Y, Takahashi R, Kawano S, Munakata S, Sugimoto K, Ishiyama S, Takahashi M, Kojima Y, Tomiki Y

Purpose: A consensus has been reached regarding diverting stoma (DS) construction in rectal cancer surgery to avoid reoperation related to anastomotic leakage. However, the incidence of stoma-related complications (SRCs) remains...
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Open versus Closed Surgery for Axillary Osmidrosis: A Meta-Analysis of Articles Published in Four Languages

Nomura M, Morioka D, Kojima Y, Tanaka R, Kadomatsu K

Background Individuals with axillary osmidrosis suffer detrimental effects to their psychosocial functioning. In Asian nations, major operations for axillary osmidrosis include subdermal excision (open surgery) and suction-curettage (closed surgery). Objective The aim of...
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Prediction of optimal bending angles of a running loop to achieve bodily protraction of a molar using the finite element method

Ryu WK, Park JH, Tai K, Kojima Y, Lee Y, Chae JM

OBJECTIVE: The purpose of this study was to predict the optimal bending angles of a running loop for bodily protraction of the mandibular first molars and to clarify the mechanics...
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Palatal en-masse retraction of segmented maxillary anterior teeth: A finite element study

Park JH, Kook YA, Kojima Y, Yun S, Chae JM

OBJECTIVE: The aim of this finite element study was to clarify the mechanics of tooth movement in palatal en-masse retraction of segmented maxillary anterior teeth by using anchor screws and...
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Lower SMI is a risk factor for dysphagia in Japanese hospitalized patients with osteoporotic vertebral and hip fracture: A retrospective study

Suseki K, Yamashita M, Kojima Y, Minegishi Y, Komiya K, Takaso M

Objectives Many patients with osteoporotic fragile fracture often suffer from dysphagia that results in malnutrition, further deterioration of physical strength, and rehabilitation difficulties. This study aims to investigate the risk factors...
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High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer

Yazaki S, Kojima Y, Yoshida H, Takamizawa S, Kitadai R, Nishikawa T, Shimoi T, Sudo K, Saito A, Okuma HS, Tanioka M, Noguchi E, Uno M, Ishikawa M, Kato T, Fujiwara Y, Ohe Y, Yonemori K

Objective Folate receptor α (FRα) is a membrane protein expressed in various solid tumors but has limited expression in normal cells. Therefore, FRα is an attractive target for cancer treatment. This...
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