Genomics Inform.  2020 Dec;18(4):e45. 10.5808/GI.2020.18.4.e45.

Updated confidence intervals for the COVID-19 antibody retention rate in the Korean population

• Kamruzzaman M
• Apio C
• Park T

• KMID: 2510360
• DOI: http://doi.org/10.5808/GI.2020.18.4.e45

Abstract

With the ongoing rise of coronavirus disease 2019 (COVID-19) pandemic across the globe, interests in COVID-19 antibody testing, also known as a serology test has grown, as a way to measure how far the infection has spread in the population and to identify individuals who may be immune. Recently, many countries reported their population based antibody titer study results. South Korea recently reported their third antibody formation rate, where it divided the study between the general population and the young male youths in their early twenties. As previously stated, these simple point estimates may be misinterpreted without proper estimation of standard error and confidence intervals. In this article, we provide an updated 95% confidence intervals for COVID-19 antibody formation rate for the Korean population using asymptotic, exact and Bayesian statistical estimation methods. As before, we found that the Wald method gives the narrowest interval among all asymptotic methods whereas mid p-value gives the narrowest among all exact methods and Jeffrey’s method gives the narrowest from Bayesian method. The most conservative 95% confidence interval estimation shows that as of 00:00 November 23, 2020, at least 69,524 people were infected but not confirmed. It also shows that more positive cases were found among the young male in their twenties (0.22%), three times that of the general public (0.051%). This thereby calls for the quarantine authorities’ need to strengthen quarantine managements for the early 20s in order to find the hidden infected people in the population.

Keyword

confidence interval; COVID-19 antibody; retention rate