Biomol Ther.
2021 Jan;29(1):31-40. 10.4062/biomolther.2020.215.
Cell Autonomous Circadian Systems and Their Relation to Inflammation
- Affiliations
-
- 1Convergence Research Center, Department of Pharmacy and Institute of Chronic Disease, Sahmyook University, Seoul 01795, Republic of Korea
- 2Department of Counseling and Psychology, Sahmyook University, Seoul 01795, Republic of Korea
- KMID: 2510122
- DOI: http://doi.org/10.4062/biomolther.2020.215
Abstract
- All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN) through external and environmental cues. Peripheral organs demonstrate circadian rhythms and circadian clock functions, and these are also observed in cultured cell lines. Every cell contains a CLOCK: BMAL1 loop for the generation of circadian rhythms. In this review, we focused on cell autonomous circadian rhythms in immune cells, the inflammatory diseases caused by disruption of circadian rhythms in hormones, and the role of clock genes in inflammatory diseases.
