J Korean Diabetes.  2020 Jun;21(2):59-63. 10.4093/jkd.2020.21.2.59.

Diabetes and Circadian Rhythm

  • 1Department of Endocrinology and Metabolism, Chosun University Hospital, Gwangju, Korea


All organisms on earth are governed by time-based biological rhythms. These biological rhythms are maintained by an endogenous circadian clock, which consists of the central clock in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks. This clock sets its own program and builds networks for circadian timekeeping. The circadian clock regulates the cellular, physiological, and metabolic systems to synchronize biological cycles with environmental cycles. The flow of life in modern society is too complex and irregular to fit every endogenous circadian clock. Recently, the impact of circadian misalignment on health issues including diabetes, obesity, cardiovascular disease, and cancer, has attracted growing interest. Several studies suggest circadian rhythm of the association with glucose homeostasis. The understanding for circadian rhythm in glucose metabolism can present an opportunity for diabetes preventive strategies and improving glycemic control for people with diabetes.


Circadian rhythm; Diabetes mellitus; Glucose intolerance
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