Ann Surg Treat Res.  2021 Jan;100(1):25-32. 10.4174/astr.2021.100.1.25.

Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer

• Lee Sy
• Lee SI
• Min BW
• Oh SC

• KMID: 2510037
• DOI: http://doi.org/10.4174/astr.2021.100.1.25

Abstract

Purpose
The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients.
Methods
A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (>51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis.Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model.
Results
In the young group, NLR > 5, LMR < 2, and PNI < 45 were significantly associated with OS with univariate analyses. dNLR > 3 and those markers showed significance for PFS. LMR < 2 was a significant marker for poor PFS (hazard ratio [HR], 5.81; P = 0.020) in the multivariate analysis. In the old group, all inflammatory markers were significantly associated with OS and PFS with univariate analyses. LMR < 2 (HR, 2.66; P = 0.016) and PNI < 45 (HR, 2.14; P = 0.016) were independently associated with OS in multivariate analyses. PLR > 150 (HR, 1.45; P = 0.036) and PNI < 45 (HR, 1.73; P = 0.002) were significant markers for PFS.
Conclusion
Systemic inflammation might be one of biologic factors that influence on prognosis of young CRC.

Keyword

Colorectal cancer; Prognosis; Systemic inflammatory markers; Young patients