Infect Chemother.  2020 Dec;52(4):461-477. 10.3947/ic.2020.52.4.461.

Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19

• Farjana M
• Moni A
• Mamun Sohag AA
• Hasan A
• Hannan A
• Hossain G
• Uddin J

• KMID: 2509879
• DOI: http://doi.org/10.3947/ic.2020.52.4.461

Abstract

Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to anti-microbial functions. Evidence suggests that vitamin C acts against inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance the immune system makes this versatile vitamin a prospective therapeutic agent amid the current situation of coronavirus disease 2019 (COVID-19). Being highly effective against the influenza virus, causing the common cold, vitamin C may also function against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its associated complications. Severe infections need higher doses of the vitamin to compensate for the augmented inflammatory response and metabolic demand that commonly occur during COVID-19. Compelling evidence also suggests that a high dose of vitamin C (1.5 g/kg body weight) in inflammatory conditions can result in effective clinical outcomes and thus can be employed to combat COVID-19. However, further studies are crucial to delineate the mechanism underlying the action of vitamin C against COVID-19. The current review aims to reposition vitamin C as an alternative approach for alleviating COVID-19-associated complications.

Keyword

COVID-19; SARS-CoV-2; Vitamin C; Immune response; Inflammation