Child Health Nurs Res.  2020 Oct;26(4):434-444. 10.4094/chnr.2020.26.4.434.

Analysis of Characteristics of Peripheral Arterial Ischemia in Premature Babies and Effects of Nitroglycerin Patch Application

• Kim J
• Lee JW
• Kim DY

• KMID: 2508592
• DOI: http://doi.org/10.4094/chnr.2020.26.4.434

Abstract

Purpose
The aim of this retrospective study was to analyze the characteristics of peripheral arterial ischemia and tissue necrosis in premature babies, as well as the effects of nitroglycerin.
Methods
In total, 513 newborns were enrolled who were admitted to the neonatal intensive care unit with a gestational age of 34 weeks or younger. Data were collected on general personal and clinical information, peripheral arterial ischemia, and nitroglycerin patch application in the premature infants. The collected data were analyzed using the x² test, t-test, Mann-Whitney U test, logistic regression.
Results
Thirty-six (7.0%) infants had peripheral arterial ischemia, while 477 (93.0%) infants did not. Lower gestational age (x²=35.97, p<.001), lower birth weight (x²=29.40, p<.001), lower blood pressure (x²=23.10, p<.001), and insertion of an umbilical artery catheter (p<.001) were significantly associated with the occurrence of peripheral arterial ischemia. Among the preterm infants in whom nitroglycerin patches were applied, 30 (83.3%) premature infants without necrosis improved without complications, 4 (11.1%) showed hypotension, and 2 (5.6%) showed skin damage.
Conclusion
Based on a review of our experiences with nitroglycerin patches, we recommend closely observing skin color and using nitroglycerin patches on the skin to help improve flow in premature infants with peripheral arterial ischemia.

Keyword

Ischemia; Necrosis; Nitroglycerin; Therapeutic use; Transdermal patch