Psychiatry Investig.  2020 Sep;17(9):934-940. 10.30773/pi.2020.0133.

Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population

• Lv Y
• Sun Y
• Wang GY
• Yin J
• Li CJ
• Luo YY
• Luan ZL

• KMID: 2507269
• DOI: http://doi.org/10.30773/pi.2020.0133

Abstract

Objective
Schizophrenia is one of the most devastating neuropsychiatric disorders. Genetic epidemiological studies have confirmed that schizophrenia is a genetic disease. Genes promoting neurodevelopment may be potential candidates for schizophrenia. As an adaptor linking a number of tyrosine kinase receptors in multiple intracellular signaling cascades, Src homology 2 domain containing transforming protein 3 (SHC3) is a member of the Shc-like adaptor protein family, and expressed predominantly in the mature neurons of the central nervous system (CNS). In the present study, we aimed to investigate the association of SHC3 and schizophrenia.
Methods
An independent case-control association study was performed in a sample including 710 schizophrenia patients and 1314 healthy controls from a Northeast Chinese Han population.
Results
The allelic and genotypic association analyses showed that four SNPs in SHC3 significantly associated with schizophrenia (rs2316280, rs4877041, rs944485 and rs7021743). The haplotype composing of these four SNPs also showed significantly individual and global association with schizophrenia.
Conclusion
Our present results suggest SHC3 as a susceptibility gene for schizophrenia.

Keyword

Schizophrenia, Association, Single nucleotide polymorphism (SNP), SHC3, Neurodevelopment