Korean J Pain.  2020 Oct;33(4):395-399. 10.3344/kjp.2020.33.4.395.

Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain

• Seong H
• Kim RK
• Shin Y
• Lee HW
• Koh JC

• KMID: 2507145
• DOI: http://doi.org/10.3344/kjp.2020.33.4.395

Abstract

Background
This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage.
Methods
Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.
Results
Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.
Conclusions
Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.

Keyword

Chronic Pain; Collagen; Connective Tissue; Injections; Musculoskeletal Pain; Pain Management; Procollagen; Regenerative Medicinec

Figure

• 

  Fig. 1 Flow chart indicating patient selection and exclusion criteria.

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  Fig. 2 Change in the numerical rating scale (NRS) score 1 month after porcine atelocollagen injection.

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